DECEMBER 1, 2017 Patricia Inacio, PhDBY PATRICIA INACIO, PHD
Researchers at the MRC Centre for Regenerative Medicine, University of Edinburg have discovered a mechanism that accelerates reprogramming of cells into any other cell type. The finding may help boost drug discovery and cellular therapies for several diseases, including multiple sclerosis (MS).
The study reporting the findings, “Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming,” was published in the journal Cell Stem Cell.
Cellular reprogramming is a process by which scientists can convert a mature cell, like a fibroblast (a connective tissue cell) into a neuron (nerve cell). This conversion can occur directly, or cells may undergo an intermediate phase where they acquire a stem-cell like phenotype. This means these cells – called induced pluripotent stem cells – have the potential to become any type of cell found in the body.
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